High-Dose Statin for Every Stroke

High-Dose Statin for Every Stroke

Statins exert neuroprotective, microvascular, and antiinflammatory beneficial effects in animal stroke models, independent of their lipid-lowering capabilities. These are seen at the highest doses with a dose–response effect. Observational studies show that statin use is associated with improved outcome in patients with ischemic stroke, presumably a result of the pleiotropic effects suggested i...

Controversies in Stroke High-Dose Statin for Every Stroke The Good, the Bad, and the Unknown

Statins exert neuroprotective, microvascular, and antiinflammatory beneficial effects in animal stroke models, independent of their lipid-lowering capabilities. These are seen at the highest doses with a dose–response effect. Observational studies show that statin use is associated with improved outcome in patients with ischemic stroke, presumably a result of the pleiotropic effects suggested i...

High-dose statin for every stroke: the good, the bad, and the unknown.

Statins exert neuroprotective, microvascular, and antiinflammatory beneficial effects in animal stroke models, independent of their lipid-lowering capabilities. These are seen at the highest doses with a dose–response effect. Observational studies show that statin use is associated with improved outcome in patients with ischemic stroke, presumably a result of the pleiotropic effects suggested i...

High dose atorvastatin after stroke or transient ischaemic attack (SPARCL)--does every stroke patient in Pakistan deserve a statin?

High-dose statin, not so IDEAL?

Tikkanen et al. (1) present an interesting post-hoc analysis of the IDEAL (Incremental Decrease in Endpoints Through Aggressive Lipid Lowering) study with a novel statistical method using all vascular rather than just the first cardiovascular events recorded, and they propose highly significant p values in support of using top-dose atorvastatin (80 mg/day) versus "standard" dose simvastatin (20...